PIHKAL: A Chemical Love Story

Product Information

MDMA - MDMA strongly amplifies the physical, visual, and cognitive effects of 2C-B. This combination is reported to produce strong sensations of euphoric pleasure manifested through distinct body highs, headspaces and uniquely colorful visuals. The synergy between these substances is unpredictable, and it is advised to start with markedly lower doses than one would take for both substances individually. This combination may increase the neurotoxic effects of MDMA, based on its similarity to LSD, which has been found to increase MDMA neurotoxicity. [16] It is generally agreed that the so-called "War on Drugs" has not been a success, and a growing minority view decriminalization as a viable alternative. An interesting consequence of such a change, should it occur, would be a revival of research into the uses of consciousness-altering psychedelic drugs such as LSD and MDMA ("ecstasy"), which has languished since the early 1970s. A key figure in this field is Alexander (Sasha) Shulgin, whose life story is an interesting one. After serving in the U.S. Navy during the Second World War, he did a Ph.D. in biochemistry at U.C. Berkeley, and joined the Dow Chemical Company. Around 1960 he took the psychedelic drug mescaline, and became interested in its chemistry, and that of its derivatives. Over the next 30 years he synthesized and characterized hundreds of psychedelic compounds. The subjective effects of each were first tested by Shulgin himself, and then by members of his research group. This consisted of a dozen or so close friends, who would meet on weekends at the Shulgins' home, try out new compounds, and afterwards write descriptions of their experiences. Illicit use of some of these compounds subsequently became widespread, as in MDMA (originally synthesized around 1912), DOM (STP), and 2C-B. Surprisingly, Shulgin for many years also acted as an advisor to the U.S. Drug Enforcement Administration (DEA), analyzing contraband and giving expert testimony in drug trials. In 1973 the DEA awarded him a medal for his "significant personal efforts to help eliminate drug abuse", and he was close friends with a number of top DEA agents. Two DEA agents even got married at his home. Inclusion of 4-bromo-2,5-dimethoxyphenethylamine (2C -B) in Schedule II of the Convention on Psychotropic Substances of 1971". United Nations Office on Drugs and Crime (UNODC). March 20, 2001. CND Dec.44/1 . Retrieved December 10, 2019. Alexander Shulgin lived his life in a unique position where his expertise in the field of mind altering drugs gave him the freedom to dance the lines of legality in the design, synthesis, and consumption of new substances.

As literature PIHKAL and TIHKAL are unusual for their hybridity. Some of the best postwar writing has been that which has managed to span the chasm between art and science, as in Primo Levi's The Periodic Table. The Shulgins' two big books span autobiography, organic chemistry, politics, ethnobotany and psychopharmacology. Their cultural impact is likely to be profound in the coming decades. A minor flaw is that while both books have an index for chemical compounds, neither has a general index: an oversight, especially given their great length. so basically, this is a book by a chemist who has devoted his career to making and exploring psychedelics. what if you take the mescaline molecule and swap out this atom on the benzene ring? etc. etc. etc. each permutation basically gives rise to a cascade of other permutations. being that animal studies are useless for determining what psychedelic effects a human might experience from this or that chemical, he tries the compounds himself, going from a low dose upwards. if he detects a psychedelic effect and it doesn't seem terribly toxic, he then has a group of friends who take them as well and describe their experiences. the first part of the book is supposedly a novelization (presumably to provide plausible deniability in case any law enforcement agencies wanted to come after him), first in his voice, of his career as a psychedelic chemist, then in his second wife's voice, of her experience meeting him and joining him in testing his creations. Snorting of 2C-B is highly inadvisable and there are anecdotal reports of pain associated with insufflation. Extra caution is required with snorting as the dose required is much smaller than an oral dose and the onset is very rapid, often within minutes.Depending on the future legal status of these drugs and the prevailing attitudes towards them, Shulgin's accounts may end up being the only comprehensive knowledge on these substances that we ever have, making this book even more noteworthy. No sentence summarizes this book better than the Mythbusters quote, "Remember kids, the only difference between screwing around and science is writing it down." Shulgin and his experimental group conducted countless experiments on his creations, all while documenting the dosages, effects, and durations. As anyone who has done psychedelics knows, recounting the experience is at least as hard as remembering dreams. This, alone, makes the data extremely impressive. Shulgin in this book told his life's story and how he got interested in the things that made him famous (it has to do with the placebo effect and the power of the mind); how he met his wife, who co-authored this work with him; he described his little psychedelic sessions with friends in a very affectionate and effective way.

PIHKAL (Phenethylamines I Have Known And Loved) is a unique book written by renowned psychopharmacologist Alexander Shulgin and his wife Ann Shulgin. This book gives details of their research and investigations into the use of psychedelic drugs for the study of the human mind, and is also a love story. phen-ethyl-amine \fen-'eth-al-a-,men\ n. [ phenylfr. F. phène, fr. Gk. phainein, to show (from its occurrence in illuminating gas)+ ethyl (+ yl) + amine fr. NL ammonia] 1: A naturally occurring compound found in both the animal and plant kingdoms. It is an endogenous component of the human brain. 2: Any of a series of compounds containing the phenethylamine skeleton, and modified by chemical constituents at appropriate positions in the molecule. Introduction Internationally, 2C-B was added to the UN Convention on Psychotropic Substances as a Schedule II substance on March 20, 2001. [21] Tolerance to the effects of 2C-B is not built almost immediately after ingestion. There are many anecdotal reports of people ingesting this substance many days in a row (either consecutively or by redosing many many times in a row and tripping continuously for dozens of hours) with no immediate tolerance build up and still building quite slowly even under sustained exposure. PLUS ONE (+) The drug is quite certainly active. The chronology can be determined with some accuracy, but the nature of the drug’s effects are not yet apparent.Zwartsen, A.; Hondebrink, L.; Westerink, R. H. S. (2018). "Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA)". NeuroToxicology. 66: 87–97. doi: 10.1016/j.neuro.2018.03.007. ISSN 0161-813X. OCLC 47153737. PMID 29572046. PLUS THREE (+++) Not only are the chronology and the nature of a drug’s action quite clear, but ignoring its action is no longer an option. The subject is totally engaged in the experience, for better or worse. Páleníček, T.; Fujáková, M.; Brunovský, M.; Horáček, J.; Gorman, I.; Balíková, M.; Rambousek, L.; Syslová, K.; Kačer, P.; Zach, P.; Bubeníková-Valešová, V.; Tylš, F.; Kubešová, A.; Puskarčíková, J.; Höschl, C. (2013). "Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats". Psychopharmacology. 225: 75–93. doi: 10.1007/s00213-012-2797-7. eISSN 1432-2072. ISSN 0033-3158. OCLC 2409222. PMID 22842791.

It was originally transcribed into ASCII by Simson Garfinkleand was coverted into HTML by Lamont Granquist.In the 1970s, it was used in patients by a small number of psychotherapists in the United States. These therapists reported that it created a warm, empathetic bond between them and their patients, helping to break down their ego defenses and inner resistances and allowing the patient to get in touch with suppressed emotions and repressed memories. The gentle nature of 2C-B, in addition to its mild side effects and short duration, were found to be desirable traits for a therapeutic setting. [9] In the 1980s and early 1990s, several foreign companies legally manufactured the substance under the brand names "Nexus", "Erox", and "Performax" and advertised that it would alleviate impotence, frigidity, and diminished libido. It was sold at adult book and video stores, "head" shops, and some nightclubs. The DEA reported its distribution in Miami, Florida in the form of yellow pills marketed as an aphrodisiac. [ citation needed]

Règlement grand-ducal du 14 décembre 2001 modifiant l'annexe du règlement grand-ducal modifié du 4 mars 1974 concernant certaines substances toxiques. | http://legilux.public.lu/eli/etat/leg/rgd/2001/12/14/n10/jo While 2C-B has been reported as having the potential to produce transpersonal states, they are reported to occur less consistently or intensely than with classic psychedelics such as psilocybin mushrooms, mescaline, LSD, or DMT.

#100 MDA

There were some sections of this book that I found quite extraordinary and insightful. I really got what I was looking for about the effects of psychedelics/tryptamines and how they can be used as a tool to understand the mind and the human experience. There is truly a lot of good information contained in the "fictional auto-biography". Rules for a trance or psych state says the sitter. Anger cannot be acted out physically agains me or my possessions. You should talk abt whatever fantasy comes up but you cannot act it out. If you see the opportunity to die, you will not take it. Not here with me.