MY BATTLE AGAINST CANCER: Survivor protocol : foreword by Thomas Seyfried

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SO...I immediately embarked on a 75-hour water and green tea fast. Finished fasting yesterday after my GKI came in at .9, (glucose 78, ketones 4.7) and was obviously thrilled (also lost 7 more pounds...lo.)

Blatt, J.; Stitely, S. Antineuroblastoma activity of desferoxamine in human cell lines. Cancer Res. 1987, 47, 1749–1750. [ Google Scholar] Lithostat acetohydroxamic acid is a typical SCOT inhibitor used to treat bladder stones. Another inhibitor, Pimozide [ 40, 41], used to treat mental diseases, reduces cancer incidence. Several interesting compounds are highlighted in the work of Lissanti’s group, who describe potential SCOT inhibitors, the Mitoketoscine [ 42], through their structural and binding properties. Selecting the best and least toxic derivative for animal cancer models requires collaboration with pharmaceutical groups. These are my personal choices. 1 cup of V8 juice is good lycopene for a meal, 16 mg. Try to get total daily lycopenes around 50-70mg. watch out for sodim intake. Also consider around 10-20 mg per meal total. I go through a lot of catsup. Pavlova, N.N.; Zhu, J.; Thompson, C.B. The hallmarks of cancer metabolism: Still emerging. Cell Metab. 2022, 34, 355–377. [ Google Scholar] [ CrossRef] Considering the highly disappointing results from the TAILORX breast cancer study (specifically 85% of women with early breast cancer ( those with an identifiable genetic signature) received no benefited from traditional preventative treatments. How can metabolic therapies that have shown the success noted above now not be aggressively funded and researched?

Al Batran, R.; Gopal, K.; Capozzi, M.E.; Chahade, J.J.; Saleme, B.; Tabatabaei-Dakhili, S.A.; Greenwell, A.A.; Niu, J.; Almutairi, M.; Byrne, N.J.; et al. Pimozide Alleviates Hyperglycemia in Diet- Induced Obesity by inhibiting Skeletal Muscle Ketoneoxidation. Cell Metab. 2020, 31, 909–919. [ Google Scholar] [ CrossRef] Mazurek, S.; Eigenbrodt, E. The tumor metabolome. Anticancer Res. 2003, 23, 1149–1154. [ Google Scholar] [ PubMed] Apparently some (but not all) cancers can respond quite strongly to glucose lowering. There are a range of strategies that could help to achieve such glucose reduction. For example, even modest overnight fasting helps-- longer fasts could also be tried. For some, even longer fasts could be attempted, though professional medical advice would be necessary at some stage to maintain safety. Gonçalves, J.M.; Barcellos Silva, C.M.; Rivero, E.R.C.; Cordeiro, M.M.R. Inhibition of Cancer stem cells promoted by Pimozide. Clin. Exp. Pharmacol. Physiol. 2019, 46, 116–125. [ Google Scholar] [ CrossRef][ Green Version] Guy Tenenbaum is a youtuber that I’ve been following for the past 10 months but I’ve watched every video that he’s put out over the past 2 years to document his journey.

Aslam, M.N.; Bergin, I.; Naik, M.; Hampton, A.; Allen, R.; Kunkel, S.L.; Rush, H.; Varani, J. A multi-mineral natural product inhibits liver tumor formation in C57BL mice. Biol. Trace Elem. Res. 2012, 147, 267–274. [ Google Scholar] [ CrossRef][ Green Version] Bernstein, B.A.; Richardson, T.; Amundsen, C.H. Inhibition of Cholesterol biosynthesis and Acetyl-CoA synthetase by bovine Milk and Orotic acid. J. Dairy Sci. 1977, 60, 1846–1853. [ Google Scholar] [ CrossRef] [ PubMed] He’s had no traditional treatment, but simply did lots of fasting and taking supplements and he’s been diagnosed as cancer free since last June. His metastasis are gone and only the old scars remain on his bone scans. kimster, I have liked at least on a conceptual level this article https://arxiv.org/pdf/1407.7622.pdf

Moderation team

Quite a few drugs for cancer are developed from non natural substances. Many thousands of natural chemicals were tried and tested before the first chemo drug came along, and Docetaxel was derived from Yew tree sap. Maybe its made in a lab now.

Foster, D.W. Malonyl-CoA: The regulator of fatty acid synthesis and oxidation. J. Clin. Invest. 2012, 122, 1958–1959. [ Google Scholar] [ CrossRef][ Green Version]

Bonuccelli, G.; Tsirigos, A.; Whitaker-Menez, D.; Pavlides, S.; Pestell, R.G.; Chiavarina, B.; Frank, P.G.; Flomenberg, N.; Howell, A.; Martinez-Outschoorn, U.E.; et al. Ketones and lactate “fuel” tumor growth and metastasis. Cell Cycle 2010, 9, 3506–3514. [ Google Scholar] [ PubMed] Israël, M.; Schwartz, L. Inhibition of the ketolytic acetyl CoA supply to tumors could be their “Achilles heel”. Int. J. Cancer 2020, 147, 1755–1757. [ Google Scholar] [ CrossRef] I want Radium223, but docs don't really know if that will work, and there are not many add on drugs to make it work better. The other question I ask myself is whether having the testicles removed might be a better option than ADT even it means no sex for the rest of what could be a longer life. Okumura, S.; Konishi, Y.; Narukawa, M.; Sugiura, Y.; Yoshimoto, S.; Arai, Y.; Sato, S.; Yoshida, Y.; Tsuji, S.; Uemura, K.; et al. Gut bacteria Identified in colorectal cancer patients promote tumorigenesis via butyrate secretion. Nat. Commun. 2021, 12, 5674. [ Google Scholar] [ CrossRef]