Quality of Life Kinoko Platinum AHCC 750 Mg 60 Ct by Quality of Life

Product Information

In the absence of an available vaccine against coronavirus, there is broad interest in alternative approaches to immune system maintenance.

Patients of childbearing age must agree to use effective methods of contraception (oral contraceptives, condoms, etc.) while on study.

Results

While we have vaccines for HPV, there are fewer treatments for existing high-risk cases,” says Homma. The research led by Judith A. Smith at the University of Texas Health Science Center at Houston McGovern Medical School, and funded by AminoUp, revealed that AHCC could help clear HPV virus infection in cervical cancer cell lines and mouse models. Judith A. Smith 1,2* Anjali A. Gaikwad 1 Lata Mathew 1 Barbara Rech 3 Jonathan P. Faro 4 Joseph A. Lucci III 1,2 Yu Bai 5 Randall J. Olsen 6 Teresa T. Byrd 1 Women over 30 years of age who have an HPV positive test and normal/negative cytology, atypical cells, ASCUS, or CIN1 or CIN2 cervical dysplasia within 3 months of study entry. This minimized potential confounders such as immune modulation that may possibly clear the infection, which is common in women under the age of 26. One supplement being scrutinised is produced by AminoUp, a biotech company in Sapporo, Japan, that has shown its proprietary mushroom culture extract, trademarked as AHCC, gives the immune system a natural boost. AHCC has now been investigated for a variety of applications in more than 100 scientific publications. This study was supported by the NIH-NCI Small Grants Program for Cancer Research (1R03CA212935), which had no involvement in the study design, data collection, data analysis, and interpretation or writing of the manuscript or its publication. Conflict of Interest

Now, AminoUp has begun a collaboration with the University of Texas Medical Branch, to assess whether AHCC could assist with global efforts to fight the SARS-CoV-2 virus through supporting the immune system. It is a mouse-model study. Mice are going to be infected with SARS-CoV-2 virus and we will examine the mortality change and other parameters with and without AHCC administration,” says Homma. Conclusion: Results from this phase II study demonstrated that AHCC 3 g once daily was effective to support the host immune system to eliminate persistent HPV infections and was well tolerated with no significant adverse side effects reported. The duration of AHCC supplementation required beyond the first negative result needs more evaluation to optimize success for durable outcomes. The suppression of the IFN-β level to less than 20 pg/ml correlated with clearance of HPV infections and merits further evaluation as a clinical tool for monitoring patients with HPV infections. AminoUp has worked to improve human immunity for more than 35 years. Its approach is simple: to enhance the natural ability of foods that positively affect human health. In conclusion, the results from this phase II study demonstrated that AHCC 3 g once daily was effective to support the host immune system to clear persistent HPV infections and was well tolerated with no significant adverse side effects reported. The duration of AHCC supplementation required beyond the first negative result needs more evaluation to optimize durable outcomes based on both HPV infection status and the target IFN-β level. Data Availability Statement

Objective: There is currently no effective medicine or supplement for clearance of high risk- human papillomavirus (HR-HPV) infections. We have taken a systematic approach evaluating the potential use of AHCC supplementation to support clearance of HR-HPV infections. The primary objective of this research was to evaluate AHCC supplementation to modulation of the host immune system to clear HR-HPV infections from bench to bedside.

Worldwide, cervical cancer is the fourth most common malignancy in women and a major cause of morbidity and mortality ( 1). It accounts for nearly 10% of all cancers, and ~265,700 women die from this disease every year worldwide ( 1). The etiology of cervical cancer has been identified and confirmed associated with high risk-human papillomavirus (HR-HPV) ( 2– 5). The human papillomavirus (HPV) is classified as a non-enveloped, double stranded DNA virus that generally infects the epithelial layer of cells including cutaneous and mucosal surfaces and associated with benign warts, carcinoma in situ and ultimately malignant lesions ( 6, 7). When HR-HPV infections persist overtime, patients have an increased risk of developing cervical cancer ( 8). In traditional Chinese medicine, mushrooms have been used to modify immunity,” says Dr Kohei Homma, AminoUp’s executive senior director of business development. “Our research scientists were motivated to understand the immunological benefit of mushrooms.” The proprietary, standardized extract of cultured Lentinula edodes mycelia, AHCC (Amino Up Chemical Co. Ltd, Sapporo, Japan), was developed in Japan in 1992. Several studies have reported a variety of therapeutic effects, including antioxidant and anticancer activity and improvement of immune response ( 9, 10). In animal studies, AHCC has shown the ability to treat and prevent cancer, and modulate the immune system to prevent infectious processes ( 9– 11). Gao et al. demonstrated the immunomodulating effects of AHCC in a study that showed enhanced antigen (Ag) activation of CD4 (+) and CD8 (+) T cells, and the increased frequency of tumor Ag-specific IFN-gamma producing CD8 (+) T cells as well as increases in cell numbers of NK cells and gamma delta T cells ( 10). In clinical studies AHCC has demonstrated benefit to decrease risk of infection and ameliorate symptoms of existing infections ( 9– 11, 13). Since studies have demonstrated AHCC induces apoptosis ( 12– 14), it is possible that AHCC may also prevent/delay tumor growth regardless of the role of HR-HPV.

Data Availability Statement

BENEFITS. Our High Strength Active Hexose Correlated Compound contains a potent mix of specially selected mushrooms to boost the immune system.