Milenkovic, L. et al. Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1. Proc. Natl Acad. Sci. USA 112, 8320–8325 (2015). Rohatgi, R., Milenkovic, L. & Scott, M. P. Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372–376 (2007). Wang, X. et al. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell 151, 372–383 (2012). Zhao, C. et al. Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells. Science https://doi.org/10.1126/science.aal3485 (2017).

Rudin, C. M. et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 361, 1173–1178 (2009). This diagram shows that they eat a lot of beetles, along with caterpillars and earthworms. Most people are aware that hedgehogs are mostly insect eaters. Gilbane, A. J., Denton, C. P. & Holmes, A. M. Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells. Arthritis Res. Ther. 15, 215 (2013). Tabata, T., Eaton, S. & Kornberg, T. B. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 6, 2635–2645 (1992). For reasons of hygiene and safety, personal grooming products, cosmetics or items of intimate clothing cannot be returned.Luchetti, G. et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. Elife https://doi.org/10.7554/eLife.20304 (2016).

In a class of autoprocessing proteins, removal of a middle segment, encoded by a mobile element, followed by ligation of the amino and carboxy termini through formation of a new peptide bond. The protein self-splicing reaction shares its initiating mechanism and a thioester intermediate with Hedgehog autoprocessing. Resistance–nodulation–division (RND) transporters Rhim, A. D. et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735–747 (2014). Griffiths, S. C. et al. Hedgehog-interacting protein is a multimodal antagonist of Hedgehog signalling. Nat. Commun. 12, 7171 (2021).

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Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003;3(12):903–11. Williams, E. H. et al. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc. Natl Acad. Sci. USA 107, 5869–5874 (2010).